The Science of MORE
Science that delivers measurable impact
Grounded in affective neuroscience and gold-standard clinical research, MORE targets the mechanisms that drive suffering—and the pathways that restore wellbeing.
Backed by the strongest evidence of any psychological treatment for co-occurring addiction, chronic pain, and emotional distress.
MORE reduces addictive behavior by strengthening self-regulation in the brain
Garland et al 2022 Science Advances
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MORE restores the brain's ability to savor natural healthy pleasure and joy
Garland et al 2025 JAMA Psychiatry
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3x as effective as standard therapy
Garland EL, Hanley AW, Nakamura Y, et al. Mindfulness-Oriented Recovery Enhancement vs supportive group therapy for co-occurring opioid misuse and chronic pain in primary care: A randomized clinical trial. JAMA internal medicine. 2022;182(4):407-417.
→Read Research50% reduction in drug cravings
Cooperman NA, Hanley AW, Kline A, Garland EL. A pilot randomized clinical trial of mindfulness-oriented recovery enhancement as an adjunct to methadone treatment for people with opioid use disorder and chronic pain: Impact on illicit drug use, health, and well-being. Journal of Substance Abuse Treatment. Published online 2021:108468.
→Read Research59% reduction in treatment dropout
Cooperman NA, Lu SE, Hanley AW, et al. Telehealth mindfulness-oriented recovery enhancement vs usual care in individuals with opioid use disorder and pain: a randomized clinical trial. JAMA psychiatry. 2024;81(4):338-346.
→Read Research42% reduction in drug relapse
Cooperman NA, Lu SE, Hanley AW, et al. Telehealth mindfulness-oriented recovery enhancement vs usual care in individuals with opioid use disorder and pain: a randomized clinical trial. JAMA psychiatry. 2024;81(4):338-346.
→Read Research30% reduction in acute pain
Garland EL, Baker AK, Larsen P, et al. Randomized Controlled Trial of Brief Mindfulness Training and Hypnotic Suggestion for Acute Pain Relief in the Hospital Setting. Journal of General Internal Medicine. 2017;32(10):1106-1113
→Read Research45% reduction in post-operative pain
Hanley AW, Gililland J, Garland EL. To be mindful of the breath or pain: Comparing two brief preoperative mindfulness techniques for total joint arthroplasty patients. Journal of consulting and clinical psychology. 2021;89(7):590.
→Read Research59% success rate in treating chronic pain
Garland EL, Hanley AW, Nakamura Y, et al. Mindfulness-Oriented Recovery Enhancement vs supportive group therapy for co-occurring opioid misuse and chronic pain in primary care: A randomized clinical trial. JAMA internal medicine. 2022;182(4):407-417.
→Read Research43% reduction in anxiety
Hanley AW, Gililland J, Erickson J, et al. Brief preoperative mind–body therapies for total joint arthroplasty patients: a randomized controlled trial. Pain. 2021;162(6):1749-1757.
→Read Research38% improvement in depression
Garland EL, Hanley AW, Nakamura Y, et al. Mindfulness-Oriented Recovery Enhancement vs supportive group therapy for co-occurring opioid misuse and chronic pain in primary care: A randomized clinical trial. JAMA internal medicine. 2022;182(4):407-417
→Read Research59% success rate in treating PTSD
Parisi, A., Hudak, J., Froeliger, B., & Garland, E. L. (2023). Mindfulness-Oriented Recovery Enhancement reduces post-traumatic stress via reappraisal among patients with chronic pain and co-occurring opioid misuse. Nature Mental Health, 1(7), 489-500.
→Read ResearchMORE reduces drug relapse by 42%, addiction treatment dropout by 59%, and days of drug use by 36%→
MORE reduces drug craving by 50%→, MORE reduces craving in people with alcohol use disorder by 27%→
MORE reduces cigarette craving by 30%→ with 36% of patients reducing their dose by 50% or more→
A single, 15-minute MORE mindfulness practice reduces acute pain by 30%→ post-operative pain by 49%→ and anxiety by 43%→
MORE reduces chronic pain by 25% and sustains relief for 9+ months→
MORE increases positive emotions by 2.75 times more than standard group therapy→
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The Science of MORE
Evidence-based therapy for addiction and pain, targeting unhealthy coping.
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One Therapy for All
One therapy for addiction, pain, and trauma—targeting shared processes.
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What is MORE?
Evidence-based path to healing addiction, chronic pain, and suffering.
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Reclaiming Inner Resources
We all have the innate capacity to radically shift our attention
Learn MOREImplementing MORE in Health Care
- Kaiser Permanente - Washington
- John Hopkins Medical School - Maryland
- Mt. Sinai Hospital - New York
- Intermountain Health Care - Utah
- Arkansas Department of Human Services - Arkansas
- Southwest Care Center - New Mexico
- New Roads Behavioral Health - Utah
- Medical University of South Carolina - South Carolina
- University of Utah Health - Utah
- Philadelphia Veterans Affairs Medical Center - Pennsylvania
- Turning Point Center - Utah
- Ralph H. Johnson Veterans Affairs Medical Center - South Carolina
- Essentia Health - Minnesota
- Harvard University, Brigham and Women’s Hospital - Massachusetts
- VA Medical Center - Hawaii
- University of California San Diego Health - California
- Rutgers Robert Wood Johnson Medical School - New Jersey
- Henrico Area SUD, MH Outpatient Services, and Court Services - Virginia
- Ventura County Behavioral Health - California
- Hampshire County Jail and House of Correction - Massachusetts
- Memorial Sloan Kettering Cancer Center - New York
- University of North Carolina at Chapel Hill - North Carolina
- Texas A&M University - Texas
- University of Washington Medicine - Washington
- Community Counseling and Correction Services - Montana
- Emory University School of Medicine - Georgia
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